Radio-protective role of antioxidant agents

نویسندگان

  • Alireza Shirazi
  • Ehsan Mihandoost
  • Seied Rabie Mahdavi
  • Mehran Mohseni
چکیده

Ionizing radiation interacts with biological systems to produce reactive oxygen species and reactive nitrogen species which attack various cellular components. Radio-protectors act as prophylactic agents to shield healthy cells and tissues from the harmful effects of radiation. Past research on synthetic radio-protectors has brought little success, primarily due to the various toxicity-related problems. Results of experimental research show that antioxidant nutrients, such as vitamin E and herbal products and melatonin, are protective against the damaging effects of radiation, with less toxicity and side effects. Therefore, we propose that in the future, antioxidant radio-protective agents may improve the therapeutic index in radiation oncology treatments.

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عنوان ژورنال:

دوره 6  شماره 

صفحات  -

تاریخ انتشار 2012